Pale cells in the Epidermis
For me I think of Acrodermatitis enteropathica, Necrolytic migratiory erythema, Pellagra and Epidermolytic hyperkeratosis.
Here the clear cells are usually in the upper third of the epidermis.
You can also get clear cell neoplasms where processing removes glycogen, mucin or lipid from the cells. eg Clear cell acanthoma and clear cell variants of other tumours or nevi.
Sebaceous gland tumours and metastatic renal tumours are also clear celled.
Vacuolisation of keratinocytes usually occurs because of a processing artefact but remember papilloma virus causing this (koilocytosis0 around a shrunken raisin like nucleous in the upper spinous layer.
Individual and nests of pale cells can be seen in the epidermis with the conditions causing Pagetoid spread.
